Spontaneous type II diabetes GK rats progress extremely similarly to human non-obese type II diabetes.
GK rats have normal blood glucose levels during the neonatal period and do not exhibit hyperglycemia within 3 weeks after birth, but develop into dominant type 2 diabetes in adulthood.
Its main features include impaired insulin secretion, reduced number of pancreatic β-cells, mild fasting hyperglycemia, significant postprandial hyperglycemia, increased hepatic glycogen generation, hyperinsuline
GK rats are non-insulin dependent, non-obese spontaneous type II diabetes animal models used for research on the pathogenesis of diabetes.
After the onset of diabetes, there is a rapid increase in blood glucose and a decrease in insulin secretion, followed by complications such as retinopathy, microvascular disease, neuropathy, and kidney disease. Unlike other rodent models of type II diabetes, GK rats are non-obese.
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