Products
C3H mice
were obtained in 1920 by Strong through hybridization of Bagg albino female mice and DBA male mice with high incidence of breast tumors, followed by inbreeding. C3H/He mice were introduced to the Institute of Laboratory Animal Sciences of the Chinese Academy of Medical Sciences from Olac in 1985.
Features:
High incidence of breast cancer, with a natural occurrence rate of 85%-100% in female mice aged 6-10 months. Breast cancer is transmitted through milk rather than the placenta. The incidence of liver cancer in female mice aged 14 months is 85%.
High complement activity, low interferon production.
High incidence of diarrhea in young mice.
Sensitive to rabies virus.
Resistant to Bacillus anthracis.
High activity of hydrogen peroxide in blood, male mice are sensitive to ammonia, chloroform, turpent
Applications
Mainly used for research in oncology, physiology, nuclear medicine, and immunology.
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