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    SHR Rat
    In 1963, Okamoto from KyotoschoolofMedicine used male WistarKyoto rats with significant hypertension symptoms and female rats with mild hypertension symptoms for mating, and then continued to select for spontaneous hypertension through sibling mating. In 1969, the 13th generation of this strain was introduced to NIH and named SHR.
    Features:

    After birth, the blood pressure of SHR rats continues to rise with age. At 3-4 months, it enters the established phase of hypertension, and at 6 months, the blood pressure reaches its highest level. In the early stages of life, SHR rats have increased sympathetic activity. Although their blood pressure is normal at 4 weeks old, their heart weight increases. As blood pressure rises, they further develop cardiovascular complications.

    Applications

    Normal rat systolic blood pressure is 110-120 mmHg, while SHR has a blood pressure of around 200 mmHg after breeding.

    In addition to the characteristic of 100% spontaneous hypertension, it also has hypertensive cardiovascular disease, making it suitable for research on human hypertension.

    Physiological data

    品系周龄

    SHR（8 weeks）

    指标

    单位

    雌

    雄

    白细胞计数

    WBC (109/L)

    3.92±0.41

    3.97±1.09

    中性粒细胞计数

    Neu (109/L)

    0.45±0.09

    0.54±0.2

    淋巴细胞计数

    Lym (109/L)

    3.24±0.37

    3.17±0.85

    单核细胞计数

    Mon (109/L)

    0.19±0.04

    0.22±0.07

    嗜酸性粒细胞计数

    Eos (109/L)

    0.03±0.01

    0.03±0.01

    嗜碱性粒细胞计数

    Bas (109/L)

    0.01±0.01

    0.01±0.01

    嗜中性粒细胞比例

    Neu (%)

    11.35±2.18

    13.38±3.17

    淋巴细胞比例

    Lym (%)

    82.48±2.85

    80.03±3.71

    单核细胞比例

    Mon (%)

    4.91±0.7

    5.47±0.6

    嗜酸性粒细胞比例

    Eos (%)

    0.86±0.3

    0.77±0.21

    嗜碱性粒细胞比例

    Bas (%)

    0.4±0.16

    0.35±0.12

    红细胞计数

    RBC (1012/L)

    6.68±0.28

    6.17±1.03

    血红蛋白浓度

    HGB (g/L)

    124.1±5.79

    121.6±18.64

    红细胞压积

    HCT (%)

    35.69±1.4

    34.35±5.28

    平均红细胞体积

    MCV (fL)

    53.44±0.9

    55.86±1.8

    平均红细胞血红蛋白含量

    MCH (pg)

    18.58±0.27

    19.79±1.18

    平均红细胞血红蛋白浓度

    MCHC (g/L)

    347.6±4.72

    354.3±11.46

    红细胞分布宽度变异系数

    RDW-CV (%)

    11.09±0.14

    11.61±0.69

    红细胞分布宽度标准差

    RDW-SD (fL)

    24.35±0.34

    26.02±2.14

    血小板计数

    PLT (10^9/L)

    770.8±63.08

    581±376.11

    平均血小板体积

    MPV (fL)

    6.76±0.11

    6.84±0.23

    血小板体积分布宽度

    PDW

    15.52±0.06

    15.88±0.58

    血小板压积

    PCT (%)

    0.52±0.04

    0.4±0.26

    品系周龄

    SHR（8 weeks）

    指标

    单位

    雄

    雌

    谷丙转氨酶

    ALT

    U/L

    43.72±5.36

    41.5±8.37

    谷草转氨酶

    AST

    U/L

    202.4±26.77

    188.24±21.43

    血清甘油三酯

    TG

    mmol/L

    0.31±0.03

    0.45±0.08

    胆固醇

    TC

    mmol/L

    1.54±0.13

    1.88±0.29

    血糖

    Glu-G

    mmol/L

    3.54±0.76

    3.7±0.48

    碱性磷酸酶

    ALP

    U/L

    307.8±40.05

    198.6±25.43

    γ-谷氨酰转肽酶

    γ-GT

    U/L

    1.47±0.4

    1.96±0.25

    血清总蛋白

    TP

    g/L

    54.22±2.88

    54.35±3.6

    α-淀粉酶

    α-AMY

    U/L

    1530.81±108.99

    847.21±135.3

    肌酸激酶

    CK

    U/L

    1833.59±450.89

    1592.56±324.88

    乳酸脱氢酶

    LDH

    U/L

    2000.44±328.12

    1839.61±303.3

    血清白蛋白

    ALB Ⅱ

    g/L

    31.86±1.53

    31.85±2.3

    脂肪酶

    LIP

    U/L

    19.07±33.36

    9.06±1.59

    尿素氮

    UREA

    mmol/L

    8.22±0.55

    7.08±0.65

    血清钙

    Ca

    mmol/L

    2.11±0.09

    2.08±0.08

    血清磷

    P

    mmol/L

    2.57±0.17

    2.31±0.23

    血清镁

    Mg Ⅱ

    mmol/L

    1.26±0.09

    1.22±0.08
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